(Background and matrix will be ignored if not used by selected method.)

For consistency with the other methods, the Shannon entropy scores have been scaled to the range [0,1] and then subtracted from 1, so that higher scores indicate greater conservation.

  

  OR

  

 

Please cite the following paper if you use this tool:

Capra JA and Singh M. Predicting functionally important residues from sequence conservation. Bioinformatics, 23(15):1875-82, 2007.

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